Toksook Bay is one of three villages located on Nelson Island, across from
Nunivak Island. The area has been utilized by Yup'ik Eskimos for thousands of years, but the community wasn't established until 1964, when many people relocated from Nightmute. The city was incorporated in 1972.
Residents of Toksook Bay rely on fishing and subsistence activities. Coastal Villages Seafood, Inc. processes halibut and salmon in Toksook. Year-round chartered and scheduled air service are available.