Saint Francis Medical Center is a Catholic healthcare provider, established in 1875 on Judeo-Christian principles. In 1875, a trio of nuns, Sisters Philimena, Engelberta and Felicitas arrived in
Cape Girardeau ready to start their second mission. Shortly after arriving, the Sisters rented a two-story frame house, which accommodated 12 patients. This humble beginning has led to their 249-bed regional medical center.
