Cayce is located in Lexington County along Highway 48 near the Congaree River. Cayce is a suburb of Columbia, located southwest of that city.
Cayce is part of the Columbia, South Carolina metro area.
With a rich historical heritage, the City of Cayce includes the site of one of the earliest European settlements in what was then known as the "back country." Cayce also contains the site of Fort Granby, where several important Revolutionary War battles were fought. In May 1914, when the city was formed, the name Cayce was chosen to honor one of its prominent citizens, William J. Cayce.
The Congaree River has always played a dominant role of strategic importance in Cayces development. There are a number of beautiful parks in the City of Cayce that provide a variety of facilities as well as a public boating facility.