USCS was established primarily to avert what could have been a serious health car problem. In 1967, the
Spartanburg General Hospital announced it was phasing out its diploma program for registered nurses. A citezens' commettee investigated the situation and ultimately requested that
Spartanburg be included in the University of South Carolina system. The Spartanburg Regional Campus, as the two-year school was first known, opened its doors in the fall of 1967 to 177 students, many whom pursued an associate of science degree in technical nursing.