Chillicothe is located north of
Abilene between
Quanah and
Vernon along US 287 on Wanderers' Creek.
It lies in Hardeman County just south of the Oklahoma/Texas state line.
Chillicothe is called the Iris Village because of the many iris found in the town. The population was 1,411 in 1950, 1,161 in 1960, 1,116 in 1970, and 1,052 in 1980. In 1990 the population was 816.