Portage Creek is located in Dillingham Census Area, within the Southwest Region, just 30 miles southeast of Dillingham.
Portage Creek was so named because it was used to portage boats from the Nushagak River to the Kvichak River, so that travelers could avoid the open waters of Bristol Bay. The town site was once used by the Yup'ik Eskimos as an overnight summer camp. A BIA school was established in Portage Creek in the 1960s. Today, the village is a popular recreational fishing and camping site during the summer months. Most residents depend to some extent on subsistence activities for various food sources.