Tuscumbia is located in Colbert County (North Region), in the NW corner of Alabama near the Tennessee and Mississippi borders along Highway 72 on the banks of the Tennessee River near Florence, placing it as part of the Florence, Alabama metro area.
Some of the local attractions in the area are the Alabama Music Hall of Fame, Belle Mont, Coon Dog Memorial Graveyard, Ivy Green (Birthplace of Helen Keller), and the Tennesee Valley Art Center.