Cambridge is located in rural Henry County, (of which it is the county seat), in northwestern Illinois between Galesburg and Geneseo on Highway 82 about 15 miles east of Interstate 74. The population estimate for the year 2000 was about 2,200.
The nearest metropolitan area is the Quad Cities area to the northwest. The area includes the cities of Rock Island and Moline as well as Davenport, IA.