Port Huron is located in St. Clair County (is the county seat), and in the Southeast Region. It lies northeast of Detroit along Interstate 69, on the banks of the St. Clair River. Port Huron also is near the United States/Ontario border and is situated on the shore of Lake Huron.

The current population estimate is 32,338 and the city occupies an area of eight square miles. Port Huron is Thomas Edison's boyhood home and the home of the state's oldest lighthouse. Other attractions include the Thomas Edison Depot, Huron Lightship and Port Huron Museum. The Annual Port Huron to Mackinac sailboat race is held in the summer. Wintertime ushers in the annual IceFest and Silver Stick hockey tournament. Thomas Edison Park is a recently developed area comprising 3,800 feet of waterfront, where the St. Clair River and Lake Huron meet. A sheltered walkway makes walking, jogging and biking possible year-round.

Port Huron is part of the Detroit, Michigan metro area.