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Domingo is in Sandoval County, and in the Central New Mexico region. Domingo is located just southwest of Santa Fe between Santa Fe and Albuquerque along Highway 22 on the banks of the Rio Grande River near Cochiti Lake.

Domingo is part of the Albuquerque, New Mexico metro area.

The population of Santo Domingo Pueblo is approximately 2866. The approximate number of families is 453.


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