Cobleskill is located in Schoharie County 46 miles W of Albany along Interstate 88 near Max V Shaul State Park and is in the Central Region of the state. Cobleskill is part of the Albany-Schenectady-Troy, New York metro area.
Named after mill owner Jacob Kobell, plus "kil," which is Dutch for stream this was also the site of the 1778 Revolutionary War battle.