Endicott is located in Broome County 6 miles west of Binghamton between Campville and Johnson City along Highway 26 on the banks of the Susquehanna River near the Pennsylvania state line. Endicott is part of the Binghamton, New York metro area and in the Central Region of the state.
It was named for Henry Endicott, partner in the Endicott-Johnson Shoe Company.