Bristow is located in Creek County northeast of Oklahoma City along historic Route 66 just off Interstate 44 (Turner Turnpike) about 10 miles southeast of Heyburn Lake.
The town is noted for its brick streets which were constructed in the late 1800s and still in place in most areas. The Bristow Historical Museum is housed in the old railroad depot and displays artifacts of the heyday of the Route 66 express train. In addition, VFW Post 3656 maintains the Wake Island Memorial Post--a national monument and WWII memorial.
The population estimate for July 1, 1998 was 4,173, an increase of 111 since 1990.