Tuskahoma is located in southeastern Oklahoma in Pushmataha County 3 miles east of Sardis Lake along U.S. Highway 271 on the banks of the Kiamichi River. The town's name is derived from the Choctaw "tuska homma" meaning "red warrior".
The town is home to the Choctaw Nation Museum which contains artifacts dating back to the Choctaw Trail of Tears from Mississippi and Alabama beginning in 1831. The red brick building, built in 1883, still hosts tribal courts.