Grady county is located in south central Oklahoma southwest of Oklahoma City and has named Chickasha as its county seat.
Chickasha is home to the state's only public liberal arts college, the University of Science and Arts of Oklahoma.
Other than the Canadian River, which forms most of the northern boundary with Canadian County, the county's only major waterway is the Washita River flowing in a southeasterly direction in about the center of the county.
Major thoroughfares include the H.E. Bailey Turnpike (Interstate 44) which runs from the northeast to the southwest and U.S. Highway 81 which runs in a north-south direction and approximates at least a part of the old Chisholm Trail which was used to drive cattle to the stockyards in Kansas.
Historic sites in the county include the Oklahoma College for Women Historic District in Chickasha, the Minco Armory and the Pocasset Gymnasium.