This 110-mile segment includes a 33-mile Crater Lake Rim drive. It joins Highway 62 at the south entrance to Crater Lake National Park
, descends through pine forests, then meanders to the upper Klamath National Wildlife Refuge on Klamath Lake. The refuge is home to bald eagles, pelicans, crains, and provides many wildlife viewing sites.
Additional Highways, Byways, and Scenic Drives have been designated official Oregon Scenic Byways.