Clemson is located in Pickens County. The city is located on Highway 51, just east of the Georgia border and southwest of Greenville. Lake Keonee and Yellow Branch State Park are situated nearby.
Clemson is located within the foothills of the Blue Ridge Mountains and along the shores of Lake Hartwell. Landmarks such as Fort Hill, Tillman with its clock tower and the outdoor theater all add to Clemson's rich tradition. Great weather and proximity to natural wonders and large cities offer year-round recreational opportunities. Clemson is also home to Clemson University.
Clemson is part of the Greenville-Spartanburg-Anderson metro area.