Santee is located in Orangeburg County east of Orangeburg along Highway 6. The town is situated just off Interstate 95 in Orangeburg County, near Lake Marion.
The Town of Santee and the surrounding area offer many amenities for both visitors and residents. There are many lodging accommodations, from full service motels to lake cabins. Santee also offers several dining options from tradition Southern home cooking to traditional barbecue.
History and beauty abound in our five county region (Berkeley, Calhoun, Clarendon, Orangeburg and Sumter). There are museums, parks, flower gardens, plantation homes, nature trails, historic battle grounds, lake and river tours and much more.
There are many sporting opportunities as well. Within a 45 minute drive of Santee, golfers can play 15, 18 holes courses.
There is also a Santee, California.