Mission is located in Todd County, on the Rosebud Indian Reservation in Black Hills, Badlands & Lakes Region, where US 18 meets Hwy 26.
Rosebud Reservation has several communities which offer a wide variety of services, products, community and cultural events. There are also recreational opportunities, camping, golf, rodeos, pow wows, and casinos as well as many community and cultural events.
The population estimate for July 1, 1998 was 848, an increase of 118 since 1990.