Northwest of Victoria, Cuero is at the convergence of US highways 183, 77A, and 87, in central DeWitt County. It is the largest city in the county and the county seat.
The county courthouse, built in 1895-96, was restored in 1955-57. The DeWitt County Historical Museum was established in Cuero about 1974.
Cuero's population peaked about 1969 at 7,800 and had declined to 6,920 by the mid-1970s. Agribusiness still dominated the local economy, though the turkey and cotton industries had declined in significance. In the mid-1980s the population reached 7,124, and the city supported 142 businesses. The population in 1990 was 6,700.