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Memphis is located southeast of Amarillo between Clarendon and Childress along US 287 near the Prairie Dog Town Fork of the Red River, where it is the seat of Hall County.

Since the Great Depression era Memphis has continued as a farm supply center. In 1986 the city had a cotton compress, gins, a grain elevator, two banks, eight churches, four public schools, a modern medical complex, two motels, and several mercantile stores.

The route of the annual Cotton Boll Enduro, a 125-mile cross country motorcycle event held in late October, begins and ends at Memphis.

In 1990 Memphis had a population of 2,465.

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