Depue is located in north central Illinois 10 miles west of La Salle south of Interstate 80 and east of Interstate 180 on the banks of the Illinois River. The area is referred to as the "Great Bend" in the river as its course changes from a westerly flow to a southerly one.
As part a major migratory flyway for waterfowl, the Donnelley/Depue SFWA Complex facilitates the feeding, resting and harvesting of the birds. In addition, the Donnelley/DePue State Park works to coordinate these efforts with the general public who desire recreational opportunities such as fishing, hiking and hunting.