Roxboro is located in
Person County (of which it is the county seat) north of
Durham, between
Oxford and
Reidsville along US Highway 158 near
Yanceyville,
Hurdle Mills, the Flat River, Hyco Reservoir, and Mayo Reservoir. Incorporated on January 9, 1855, Roxboro is geographically centered in Person County among scenic rolling hills of the eastern Piedmont area.