Interstate 76's western terminus is in southern
Medina County at its interchange with
I-71. It heads in an easterly direction for about 15 miles before taking a quick jog north to intersect with
I-77 in the soutern
Akron area. The highway then turns northeast for about 15 miles and then heads east again where it meets
I-80 in northern
Mahoning County just west of
Meander Creek Reservoir. It then turns to the southeast, passes through
Canfield and enters Pennsylvania just southeast of
New Middletown.