Boise (pronounced "boys") City is located in the Panhandle region of Oklahoma in Cimarron County (of which it is the county seat) west of Guymon at the intersection of U.S. Highways 412, 385/287 and 56 and SRs 3 and 325. Many of these routes were established from, or near, old cattle trails. The famous Santa Fe Trail west of town, in fact parallels modern-day 54/64/412.

The rough-and-tumble area is softened somewhat with a variety of flora including buffalo grass, cacti, fields of wild flowers and yucca.

One significant site near here is Autograph Rock which bears signatures dating back to the 1840s. In addition, the Cimarron Heritage Center is a popular attraction for museum and history buffs.

The population estimate for July 1, 1998 was 1,357, a decrease of 152 since 1990.