Established on March 2nd, 1932, the Popo Agie Wilderness Area contains about 102,000 acres. It is surrounded by the Wind River Indian Reservation on the north side, and the Bridger Wilderness within the Bridger-Teton National Forest on the west. The Wilderness is inside the Shoshone National Forest. It is precisely east of the Continental Divide, 18 miles W of Lander and 135 miles W of Casper. It is reachable from Hwys 287 and 131. The topography of the area is quite interesting. Tall, jagged peaks shadow lovely streams in deep valleys in a stretch of the Wind River Mountains. Pure granite walls abound.

Popo Agie is most often associated with the Wind River Peak. At 13,225 ft, it is on the west boundary on the Bridger-Teton National Forest. There are over twenty peaks above 12,000 ft present in the area.

There are also over 300 ponds and lakes throughout the area. Montane, subalpine, and alpine vegetation zones are represented within the wilderness.