Seiling is located in northwestern Oklahoma in northern Dewey County at the intersection of U.S. Highways 270, 281, 183/SR 3 and U.S. 60/SR 51 about 10 miles north of Taloga, the county seat, and 3 miles south of the North Canadian River. The nearest sigificant body of water is Canton Lake about 15 statute miles east of town but about 25 miles by paved road.